The papers include CDs, a cookbook, correspondence, cassette tape recordings, diploma, engineering lab notebooks, magazines, map, newspapers, photographs, reel-to-reel tape recordings, scrapbooks, sketches and a survey field book.

The papers document primarily J.C. Littlejohn's education and career at Clemson College. There are a few magazines, newspapers and photographs collected by Mary Katherine Littlejohn during her service as a nurse in the European theater during World War II.

J.C. Littlejohn's engineering lab notebooks document experiments and lab work, 1906-1908. The survey field book is of Clemson pasture land, 1906; an oversize plat has been removed. The cookbook, no date, includes approximately forty recipes, primarily desserts. There is a bound volume of correspondence related to Littlejohn's retirement in 1954 as well as a scrapbook about his retirement party and a tape recording with a CD copy of that event. There is a folder of miscellaneous correspondence to J.C. and Mary Katherine Littlejohn related primarily to his career at Clemson. Littlejohn created a scrapbook related to his life that his daughter supplemented with posthumous material, 1904-1985. The correspondence includes a series of note card sketches by Professor Joe Young, 1973-1986.

There are reel-to-reel tape recordings with CD copies of interviews with J.C. Littlejohn conducted with Dr. Barnwell Rhett Turnipseed, member of the first Clemson class of 1896; James Harrison "Red" McHugh, long time Clemson employee who discusses early construction of campus buildings as well as Walter Merritt Riggs, August Schilletter, and Thomas Wister Wright; and William "Bill" Greenlee, long time Clemson resident, teamster and trash collector who remembers Thomas Clemson and early days at Clemson College.