This series contains primarily political cartoons that Strom Thurmond collected throughout his years of public service. With few exceptions, the subject of the cartoon is either Thurmond or a current event in which he was involved.

Many of the cartoons are original drawings, sent to Thurmond by the cartoonists or their editors. Originals may be identified by a brief description, such as "ink on illustration board" or "pencil and ink". If there is an inscription, it is included in the description. Cartoons without this descriptive information are photocopies, though a couple of reproductions are signed by the artist. Descriptive information is often followed by the publication in which the cartoon appeared or the topic of the cartoon. Topics are varied and include the military muzzling investigation of the early 1960s, civil rights, military topics, Thurmond's switch from the Democratic to the Republican party, Supreme Court nominations and campaigns and elections.

The printouts from the original database and a compact disc with a Microsoft Excel 2007 spreadsheet of the data are included with this series.